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The proximal sigmoid is brought up to the left lowerquadrant as an end colostomy or a rectosigmoid anastomosis is performed in the presenceof adequate blood supply to the rectum, an adequate diameter of the sigmoid lumen, andenough length of remaining rectum (preferably ? 6 cm above the anorectal junction).Either a hand-sewn or stapled colorectal anastomosis can be performed, according tosurgeon preference. Chromosomaldamage of this type is the result of what is called DNA double-strand breaks, which actuallyoccur quite often, but are normally repaired quickly (Mills 2003) Chromosomaldamage of this type is the result of what is called DNA double-strand breaks, which actuallyoccur quite often, but are normally repaired quickly (Mills 2003). Malignanttumors, on the other hand, are poorly circumscribed and arehighly invasive (see Chapter 15 for additional discussion onbenign and malignant tumors). E-cadherin hasan extensively characterized role in the epithelial-to-mesenchymal transition thatoccurs when tumors initiate metastasis.
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